Endocrine Abstracts

Introduction: Pentraxin 3 (PTX3) is an acute-phase protein that shares structural homology with C-reactive protein (CRP). PTX3 is produced in macrophages, endothelial cells, and adipocytes in response to inflammatory stimuli, whereas hepatocytes are the main source of CRP. Because obesity and metabolic syndrome (MetS) are considered chronic inflammatory states, PTX3 might be involved in the pathogenesis of obesity and MetS as well as CRP. In this study, we aimed to investigate...

Introduction: Recent studies suggested that plasma levels of osteocalcin (OC) were negatively associated with both fat mass and plasma glucose. These findings may suggest that endocrine function of the osteoblast-derived osteocalcin on fat mass/glucose homeostasis in mice also might exist in humans. The aim of this study was to determine if osteocalcin has any effect on fat distrubution in different parts of body.Methods: Eighty-six obese premenapousal w...

Introduction: It has been demonstrated that there are differences in the effect of body mass index (BMI) on the serum 25-hydroxyvitamin D levels (25-OH D); differences appeared stronger in subjects with higher BMI. In this study we aimed to assess the association between 25-OH D status and body fat distribution and caratid intima medai thickness.Methods: 86 obese premenapousal women (aged 17–55 years) and 56 women with normal BMI took part in this s...

Background: Animal studies have demonstrated relationships between Vitamin D and glucose homeostasis. There is paucity of evidence examining the relationship between the glycemic control in children with Type 1 Diabetes Mellitus (T1DM) and vitamin D status.Objective: To determine the effects of vitamin D status on the glycemic control in children and adolescents with T1DM.Methods: Retrospective data were collected on 348 children a...

Background: Animal studies have demonstrated relationship between Vitamin D and glucose homeostasis. There is paucity of evidence examining the relationship between the glycemic control in children with type 1 diabetes mellitus (T1DM) and vitamin D status.Objective: To determine the effects of vitamin D status on the glycemic control in children and adolescents with T1DM.Methods: Retrospective data were collected on 348 children an...

Introduction: Megestrol acetate (MA) has been used in various cancers as a palliative agent to treat cancer cachexia. It has glucocorticoid activity and can induce significant secondary adrenal suppression. We designed this study to determine the extent of adrenal insufficiency in cancer patients receiving MA and find out whether ther was any predictive factor for this.Methods: Thirty-one patients (11 females and 20 males, aged 48–83 years) who were...

Objective: Our purpose was to evaluate the impact of a transmission system on metabolic control of patients with diabetes.Research design and methods: This ongoing-prospective, randomized, comparative study included adult patients with type 1 (n=71) and type 2 diabetes (n=139). Consecutive patients were equally allocated into two groups. Both groups received routine care by the same health care professionals (HCPs) 3-monthly. TeleDiab g...

Introduction: A diagnosis of subacute thyroiditis (SAT) is readily suspected when patients present with a particular set of typical clinical and laboratory characteristics. We present a patient with atypical SAT who had no neck pain but presented with fever, and weight loss; had thyrotoxicosis with normal 99mTc uptake, and needed higher doses of steroids to resolve.Case report: A 57-year-old man presented with a fever (39  °C) of 2 month-durati...

Introduction: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone (TH). It is characterized by high serum concentrations of free T4 (Ft4) and usually free T3 (Ft3) accompanied by normal or slightly high serum TSH concentrations. When RTH is suspected, the diagnosis should be confirmed by direct sequencing of the TR-β gene to identify mutations....

Background and aims: Pheochromocytomas arise from chromaffin cells of adrenal medulla and sympathetic ganglia. It occurs in about 0.05 to 0.1% of patients with sustained hypertension. It is considered that about half the patients with pheochromocytoma have only paroxysmal hypertension. Pheochromocytoma is usually suggested by the history in a symptomatic patient, discovery of an incidental adrenal mass, or the family history in a patient with familial disease. We retrospective...